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Oxerutins; Hydroxyethylrutosides (HERs); Troxerutin

Proposed Uses: Hemorrhoids; Venous Insufficiency (Varicose Veins) ; Lower-leg Edema in People with Diabetes; Lymphedema; Postsurgical Edema; Vertigo

Oxerutins are derived from a bioflavonoid called rutin. This supplement has been widely used in Europe since the mid-1960s, as a treatment for conditions in which blood or lymph vessels leak fluid. Considerable evidence suggests that oxerutins are effective, but it is difficult to find this supplement in North America.

Requirements/Sources
Although they are closely related to a natural flavonoid, oxerutins are not found in food. The only way to take them is in a supplement.

Therapeutic Dosages
For varicose veins/venous insufficiency, oxerutins are usually taken in dosages ranging from 900 milligrams (mg) to 1,200 mg daily. A typical schedule is 1,000 mg daily, taken in two separate doses of 500 mg.

For treating lymphedema and postsurgical edema, a typical dosage is a good deal higher: 3,000 mg daily.

One particular oxerutin called troxerutin may be taken alone as a treatment for varicose veins, in similar dosages. There is no evidence as yet that rutin itself is effective.

About 20 studies, enrolling more than 2,000 participants, have examined oxerutins' effectiveness for treating varicose veins and venous insufficiency. Virtually all found oxerutins significantly more effective than placebo, giving substantial relief from swelling, aching, leg pains, and other uncomfortable symptoms, while causing no significant side effects.

Some evidence suggests that oxerutins might be helpful for hemorrhoids as well. A double-blind study enrolling 97 pregnant women found oxerutins (1,000 mg daily) significantly better than placebo in reducing the pain, bleeding, and inflammation of hemorrhoids.

Safety Issues
Oxerutins appear to be safe and well tolerated. In most studies, oxerutins have produced no more side effects than placebo. The most commonly observed side effects were gastrointestinal symptoms, headaches, and dizziness. Oxerutins have been given to pregnant women in some studies, with no apparent harmful effects. However, their safety for pregnant or nursing women cannot be regarded as absolutely proven. In addition, the safety of oxerutins has not been established for people with severe liver or kidney disease.

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