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NADH; Nicotinamide Adenine Dinucleotide

Proposed Uses: Jet Lag; Alzheimers Disease; Chronic Fatigue Syndrome; Depression; Parkinson's Disease; Sports Performance Enhancement

NADH, short for nicotinamide adenine dinucleotide, is an important cofactor, or "assistant," that helps enzymes. NADH plays a role in the production of energy. It also participates in the production of L-dopa, which the body turns into the neurotransmitter dopamine.

Based on this, NADH has been evaluated as a treatment for jet lag, Alzheimer's disease, Parkinson's disease, chronic fatigue syndrome, depression and as a sports supplement. However, only the first of these uses has any meaningful scientific evidence.

Sources
Healthy bodies make all the NADH they need. In reality, we don't get much NADH from our food.

Therapeutic Dosages
The typical dosage for supplemental NADH ranges from 5 to 50 mg daily, often taken under the tongue.

Therapeutic Uses
Two trials suggest NADH may be useful for enhancing mental function under conditions of inadequate sleep, such as jet lag.

Supplemental NADH has also been proposed as a treatment for Alzheimer's disease, chronic fatigue syndrome, depression, and Parkinson's disease. Additionally, it has additionally been tried as a sports performance enhancer. However, although a few studies have been performed to evaluate these potential uses, none were designed in such a way as to produce scientifically meaningful results.

Safety Issues
NADH appears to be quite safe when taken at a dosage of 5 mg daily or less. However, formal safety studies have not been completed.

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